High-performance medicine: the convergence of human and artificial intelligence.
Open source ↗Editorial note. This digital bibliography distinguishes established evidence, emerging research, regulatory guidance, and technologies still under investigation. It is educational and does not replace clinical guidelines, local regulation, or professional judgment.
Issue 01 evidence map
Explore by feature
01
The Intelligent Transformation of Healthcare
Human–AI collaboration, clinical decision support, and the regulatory context for AI-enabled medical technology.
Current FDA guidance clarifying device and non-device clinical decision support functions.
Open source ↗Authorized AI-enabled devices and regulatory information.
Open source ↗02
The Treg Revolution
Peripheral immune tolerance, FOXP3 biology, autoimmunity, transplantation, and the evolving therapeutic landscape for regulatory T cells.
Foundational discoveries concerning peripheral immune tolerance and regulatory T cells.
Open source ↗Regulation and differentiation of regulatory T cells and dysfunction in autoimmune disease.
Open source ↗Clinical promise and current limitations of Treg infusion approaches.
Open source ↗03
Can Humans Regrow Teeth?
Current regenerative endodontics versus emerging whole-tooth regeneration research targeting USAG-1.
Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling.
Open source ↗Development of a humanized anti-USAG-1 antibody toward clinical evaluation.
Open source ↗Clinical resources and position statements on regenerative endodontic procedures.
Open source ↗04
HoLEP vs Thulium
Comparative evidence for holmium and thulium laser enucleation, emphasizing outcomes, perioperative performance, and surgical expertise.
Meta-analysis of randomized controlled trials comparing HoLEP and ThuLEP.
Open source ↗Prospective randomized non-inferiority comparison of ThuFLEP and HoLEP.
Open source ↗Systematic review and meta-analysis of comparative surgical outcomes.
Open source ↗05
AI-Assisted Retinal Screening
Evidence and clinical guidance for FDA-authorized artificial intelligence applied to diabetic retinopathy screening.
Retinal photography with remote reading or FDA-approved AI algorithms is recognized as an appropriate screening strategy when used with referral pathways and appropriate follow-up.
Open source ↗Current FDA resource for authorized AI-enabled medical devices.
Open source ↗06
The Connected Clinic
Interoperability, connected workflows, remote monitoring, information exchange, and clinical action across care settings.
USCDI v3 becomes the baseline standard within the ONC Health IT Certification Program as of January 1, 2026.
Open source ↗Policies intended to improve information exchange, reduce burden, and support patient-centered care.
Open source ↗Standards-based digital health components supporting interoperable implementation of evidence-based recommendations.
Open source ↗Systematic review of remote patient monitoring outcomes.
Open source ↗07
Smart Hospitals Beyond Robotics
Hospital transformation as an integrated operating model involving digital systems, governance, workforce, cybersecurity, sustainability, and patient-centered care.
Direction for integrated, digitally enabled, sustainable, resilient, patient-focused hospitals.
Open source ↗Interoperability, data sharing, evidence-to-action, and digital health system strengthening.
Open source ↗Framework for assessing and strengthening cybersecurity and privacy in digital health information systems.
Open source ↗08
From Lab to Decision
How laboratory values become clinically meaningful through reference intervals, decision limits, context, longitudinal trends, and professional interpretation.
IFCC review distinguishing reference intervals from clinical decision limits.
Open source ↗Regulatory framework for software that presents or processes patient-specific information to support decisions.
Open source ↗09
Technology Maturity
A lifecycle view of medical technology adoption: evidence, clinical value, integration, training, service, cybersecurity, total cost of ownership, and sustainable use.
Multidisciplinary assessment of clinical, economic, ethical, social, organizational, and lifecycle implications.
Open source ↗HTA as a systematic multidisciplinary process for determining value and informing decisions.
Open source ↗Assessment criteria include functionality, interoperability, evidence alignment, scalability, maintainability, privacy, security, and patient safety.
Open source ↗Current FDA guidance landscape for AI-enabled software, cybersecurity, CDS, and digital health products.
Open source ↗Living bibliography. This page may be updated as guidance, regulatory status, and scientific evidence evolve. Links are provided to original or authoritative sources whenever possible.